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When a Texas gas store owner, Subir Chatterjee, 58, is shot inside his check cashing booth in 2002, detectives suspect his killer is someone Subir knew. With the murderer's DNA in hand, one detective refuses to retire until the case is solved.

When gambler Scott Martinez, 47, is found eviscerated by a sword in his La Mesa, CA home, investigators can't tell who is telling the truth within his inner circle.. It will take 13 years and an advance in DNA analysis to find his killer.

When the battered body of Shawna Yandell, 16, is found floating in Washington State's Yakima River in 1993, detectives first suspect those closest to her. The case grew cold until new DNA technology revealed a callous killer that no one suspected.

When Susan Woods, 30, is found beaten and drowned in her tub in America's Cowboy Capitol, suspicion falls on her estranged husband. With a suspect's DNA in hand, detectives go back to the basics to unmask a killer-cowboy living in plain sight.

When the blood-smeared car of 27-year-old Stefanie Watson is found in a Maryland parking lot her family hold out hope she's still alive. But when a jawbone is dumped in a local neighborhood, a missing persons investigation becomes a murder.

When 31-year-old Linda Slaten is brutally strangled in her Lakeland, FL home in 1981, a complex web of suspects emerges. The case takes a dramatic turn when a DNA hit exposes the sinister underbelly of a seemingly peaceful community.

A 15-year-old girl is abducted and raped by a serial killer. A photographer is trapped under the rubble of a collapsed hotel in the Haitian earthquake. A woman is beaten and slashed with scissors by a neighbor.

Eduardo and Jayne face a living nightmare when Eduardo is kidnapped, confined in a small box, brutally tortured, injected with tainted blood and shot twice. Over seven and a half desperate months, Eduardo must fight for life as Jayne fights to save him.

Acting as a good Samaritan to a 14-year-old boy, Danielle is shocked when the boy pulls a gun on her and forces her to drive to a secret location.

A young woman is abducted at knifepoint and sexually assaulted. A farmer rips his own hand off to escape from a combine harvester. And a 14-year-old girl is left for dead at her home after having her throat slit.

Residents of small-town Robeson, Pennsylvania were stunned when 23-year-old Ashley Kline went missing on New Year's Eve. The gruesome truth rocked the community.

Hannah's best friend knew something was wrong when she stopped responding to her texts. No one knew that Hannah had been abducted by someone close to her.

When beautiful Jalajhia Finklea vanished the day before her 18th birthday, her Wampanoag Tribe members immediately took action. Jalajhia's tribe and family quickly discovered that her abductor was closer to home than they thought.

When Deserae Turner didn't come home after school, her mother and friends began texting her incessantly. A massive search ensued, and 47 of her friends were questioned. Turns out her Snapchat may have been the key to the mystery.

When Molly Jane Matheson, didn't show up for work, her mother Tracy drove to check on her. Tracy's grim discovery quickly uncovered a string of related crimes that inspired Molly's family to fight for change.

Nine years after the murders of a mother and her teenage daughters, a wiretapped conversation between the suspected killer and his sister helps police to crack the case.

Thirty-two years after the killing of University of Michigan law student Jane Mixer, police use DNA found on her pantyhose to finally track down the killer.

The killing of a woman in a Virginia hotel room goes unsolved for a quarter of a century before investigators are finally able to zero in on the likely killer.

Our cameras follow Detective Manny Reyes as he investigates the 1990 murder of a Fort Worth, Texas woman. Reyes talks to the woman's two sons, who believe that her husband, Bobby, was the murderer.

DNA found on a marijuana joint in Florida in 2005 helps to solve the 1988 rape and murder of a California woman. And a cold case of murder in Illinois heats up when a jailhouse lawyer turns jailhouse snitch.

A district attorney uses a clever technique--a "John Doe indictment"--to give law enforcement officials the time they need to track down the Schoolgirl Rapist from Rochester, N. Y.

Police in Albany, N.Y., get a surprise when a killer they think targets only older women is suspected in the murder of an elderly man. And the contents of a secret storage shed holds the grisly clues to a murder that has gone cold for more than 14 years.